I have a small collection of handguns. I LOVE my sig. It is only a 380 so the stopping power is not that of a 45, but hey you don't need the stopping power with a gun as accurate as a sig.
I disagree completely with that statement and would even go as far to say that a 380 is not even an effective defense weapon, just like a 22lr. The penatration of a 380 is so bad you might not even get through leather jackets.
If you are carrying this to potentially save your life, then get at a minimum a 9mm. With 9mm Ranger SXT's or Speer Gold Dots +p+'s, you can get a hole as big as a 45acp.