Thought I'd give my 2 cents as a fellow NFR S2K and NSX owner. I'll be honest, the first time I test drove my NSX I wasn't very impressed(But wait!). Perhaps, because I'd hyped it up to be some video game speed machine. The more I drove it and switched back and forth, the more I realized how the drive was more refined and how much more I enjoyed the NSX experience. Coming from an S2K I can't imagine not having the Targa top and losing that top down feel. I daily my S2K, and consider my NSX my weekend vacation experience. Don't let a higher mileage NSX scare you as long as you have awesome maintenance records. I've got a 3 inch binder full of almost every record of service done to my 127K NSX from the previous owner and I sleep well at night knowing it's been cared for, maintained, and most importantly driven. If you're ever in the Dallas area I'd be willing to let you test drive mine to see what you think of the 5 speed.
It all comes down to what purpose will your NSX serve you?
Are you going in with the thought of selling it eventually to break even or make a profit?
Are you going to get it meticulously detailed, remove every swirl/scratch, and keep it that way?
If you plan to daily drive it, are you ok with the possibility of the occasional door ding, scratch, rock chip?
When you take a friend out for dinner are you the type to worry about your car to the extent you can't enjoy the dinner?