The main reason for the NSX bottom flow design is air bubbles. The mid-engine layout results in a long coolant loop, where the coolant goes down under the car. The engineers were super nervous about trapped air and designed the radiator path to encourage any bubbles that got pushed under the car to rise to the bleed plug. Flowing from the bottom up helps those bubbles make it to the top of the rad. This is a relatively unique requirement compared to the simple and short coolant path of the front engine cars Madhatter mentioned he has experience with. It's a mid-engine thing.I expect that the radiator inlet and outlet in a forced flow system is more a function of packaging considerations. There may have been some other design consideration that dictated the radiator connections in the NSX.
But, several NSX race cars and race radiators have swapped the inlet and outlet, likely for perceived improved cooling function. I remember reading install instructions that said you needed to fab up different hoses to accommodate the top-feed inlet.
I would love to see water temp log data between the OEM layout and Madhatter's modified path on a road course for say five laps each in full boost. I'm curious if there would be a difference.