If my body could still take it, I would do more mixed stuff but when you get older and don't heal so quick and are more injury prone, you want to take better care of your body. Also that "I have to be prepared for anything" sort of mentality starts to fade. It's not easy accepting all this man, but at some point past your mid 30's you just realize your body is declining... So for me, the slow, softer art of Jiujitsu just fits me better which is why I concentrate primarily on that. If I could take mo of a beating, I would be doing more Muaythai and more Judo. Judo is really an underrated art, but it covers that clinch so well when someone has grabbed you, your shirt collar, your arm, etc. a few movements of your foot and body position, and you are ready to throw a guy twice your size through the air and flat on his ass. A year of judo training will do a lot, and it covers that area which is more useful in street fighting much better than Jiujitsu does (and by Jiujitsu I am talking strictly the Brazilian/Gracie style and not the Japanese style). Judo will instantly land you in a superior body position on the ground, or give you the choice to walk away. But it is hard on your body. For striking as maligned as both TKD and Karate are, they have some great long distance threats, especially TKD as it is a lot of kicks and there are a few really great powerful kicks on Karate. Both of these are weak in the mid range game, where Muaythai is devastating with the use of knees and elbows. Any closer and you are in the clinch, which is pure Judo dominance land... Then on the ground you are in BJJ territory 100%. It is really good to train a year or two in each of these and be an expert in a style after that. You have to know what to pickup and what to discard. A lot of this is based on you and your body type. If you have long limbs, that reach can make you really good in the distance game. If not, you may want to concentrate elsewhere. Every art and every instructor will tell you their stuff is the best and that you just need to follow it. I disagree. I think you should really be a thinking man and see what serves you, listen to your instincts and also to your body and let them guide you through the maze. Keep what works for you and discard what may be someone unpractical for you.
Kali is great because it is good with disarming, fighting with knife, a bottle, a stick, etc. it is quite a lot of stuff you will never learn with any other art. It can even help you disarm a person with a gun in the absolute worst, most desperate scenario.
This is for men. For women I recommend a whole different set of rules because they are almost always fighting against someone stronger and bigger in a man. Striking for women is very secondary. No matter how good they become at striking, 7 of their blows = one hard blow from a man. They will be on the losing end quickly, striking will only help them "finish" an already injured man... but they should never duke it out with a guy IMO. Yet they are taught that all the time. Women have strong legs and are flexible and BJJ serves them well, because it is leverage based and equalizes their strength. Guard work is key, because if they may often end up on their back with a male attacker/rapist. They now have 4 limbs to use including two strong legs where the man has two arms as he is standing or kneeling on his legs.
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Oh and fitness is obviously 50% of the equation. So will leave this as a reminder.