It all depends on the type of sports cars you have worked on in the past, but compared to other sports cars I have owned and/or worked on, the NSX is a very well thought out sports car that is nice to work on. If you've ever worked on a 300ZX twin turbo, a 3rd Gen RX7, or a MK IV Supra Turbo, you will find the NSX to be a breeze to work on, upgrade, and maintain.
The only big difference for me was getting used to the mid-engine layout. If your going to work on the engine you have to get a good fender cover to protect the panels and paint. The OEM NSX Fender cover runs around $150 new and covers up everything. If you get the cheap ones, you will have to buy several of them to cover up the same areas that the one OEM cover does.
And like the others have said, you can look at the FAQ sections and search Prime for a boatload of how-to threads.