I think a J37-powered HSC would be perfectly positioned to capture the sports car market today, but Honda would have to slightly change focus. The original NSX was targeted at the Ferrari 328 and priced at $60,000. It gave you better performance for a fraction of the price plus Honda reliability. Consequently, Honda sold about 4,500 NSX's in the US during 1991 and 1992. As we all know, the competition got better while the NSX stayed largely the same and got more expensive. In 2005, Honda sold 248 NSX's in the US.
I think Honda needs to use the same price/performance strategy as before but change the target market this time around. Let's face it, the F430 is really not in the same market position as the 328 was back in 1989. Probably as a response to the Gallardo V10 and Audi R8, Ferrari had to move the F430 to the higher end of the price/performance spectrum to keep the clientele happy. A $200,000 near Enzo-level car should not be Honda's target.
A better target market in my opinion for an HSC-derived NSX is the Porsche 911 customer. These people buy a lot of cars and are demanding of the qualities that made the NSX so great: performance, comfort, driveability, luxury and price. The 2009 911 roster includes the following models at the following price points:
911 Carrera 3.6L RWD 345hp 1415kg $76,300
911 Carrera S 3.8L RWD 385hp 1415kg $87,000
911 Turbo 3.6L AWD 473hp 1440kg $130,000
Honda could compete very well with the following lineup:
NSX 3.7L RWD 350hp 1350kg $60,000
NSX Type-S 3.7L RWD 390hp 1300kg $75,000
NSX Type-R 3.5L Turbo SH-AWD 480hp 1400kg $90,000
All engines could be J37-derived DOHC, 8000rpm with dry-sump oiling and OEM headers. The turbo could source variable flow technology from the RDX with a smaller bore for cylinder strength. Combine with a 6-speed manual or F-1 style sportshift along the lines of what NSXGMS described and you have one wicked performer at a discount price point- the same marketing strategy that sold the original NSX in such great numbers.